Saturday, 30 May 2020
Europe - Rome

 

 

Immagine1

 

 

 

AMECRYS Project promoted during the European Researchers’ Night 2019, held on 27 September 2019 in the University of Calabria Campus, Rende, Italy. Approximately 60,000 people attended the event where CNR and UCAL researchers G. Di Profio, E. Fontananova, T. Poerio, F.P. Nicoletta showed the basic techniques in membrane preparation and illustrated general objectives, main activities and principal drivers of the project. The event contributed to the Future Tech Week 2019, promoted by the European Innovation Council (EIC) and FETFX project.
http://futuretechweek.fetfx.eu/

 

 

30/09/2019


 

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Results from the AMECRYS Project were presented at the 5th EUROPEAN CONGRESS OF APPLIED BIOTECHNOLOGY, held in Firenze, Italy, on September 15-19, 2019. The following presentation was delivered by UST researcher Maria L. Briuglia as oral presentation: Measuring Nanotemplate-enhanced Crystal Nucleation Behavior of a Monoclonal Antibody, by M.L. Briuglia, C.J.J. Gerard, D. Lamprou, J.H. ter Horst
http://www.ecce12-ecab5.org/

 

 

20/09/2019


 

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Results from the AMECRYS Project were presented at the 5th Meeting of the Italian and Spanish Crystallographic Associations (MISCA V), held in Napoli, Italy, on September 4-7, 2019. The following presentation was delivered by CNR researcher Benedetta Carrozzini as oral presentation: Crystallographic investigation on whole anti-CD20 mAb, by B. Carrozzini, H. Yang, B.D. Belviso, X. Li, W. Chen, T.F. Mastropietro, G. Di Profio, R. Caliandro, J.Y.Y. Heng
http://cristallografia.org/congresso2019/eng/detail.asp?idn=3238

 

 

09/09/2019


 

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The second AMECRYS Project’s review meeting took place on May 8th 2019 at Research Executive Agency (REA), in Brussels, showing the implementation of the new membrane-based method for anti-cancer Anti-CD20 mAb purification.

 

 

 

 

 

 

 

 

10/05/2019


 

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The 5th AMECRYS project progress meeting took place at Université libre de Bruxelles, Belgium, on 7th of May 2019.

 

 

 

 

 

 

 

 

09/05/2019


 

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A new AMECRYS paper published on Crystals (MDPI): Optimization of Vapor Diffusion Conditions for Anti-CD20 Crystallization and Scale-Up to Meso Batch, by H. Yang, B.D. Belviso, X. Li, W. Chen, T.F. Mastropietro, G. Di Profio, R. Caliandro, and J.Y.Y. Heng. Authors propose a set of optimized crystallization conditions for producing Anti-CD20 needle-shaped crystals within 24 h in a very reproducible manner and with high yield, using both vapor diffusion and meso batch methods. DOI: 10.3390/cryst9050230
https://www.mdpi.com/2073-4352/9/5/230

 

 

 

29/04/2019


 news1 130319A new AMECRYS paper published on ACS Applied Polymer Materials  (American Chemical Society):

 

Exploiting Fluoropolymers Immiscibility to Tune Surface Properties and Mass Transfer in Blend Membranes for Membrane Contactor Applications, by C. Meringolo, T. Poerio, E. Fontananova, T. F. Mastropietro, F. P. Nicoletta, G. De Filpo, E. Curcio, and G. Di Profio.
Polyvinylidene fluoride-co-hexafluoropropylene and polyvinylidene fluoride blend membranes, with interconnected channels decorated with polymer crystallites, were produced by a two-step phase separation technique, using nontoxic solvents and without any chemical additive as pore forming. DOI: 10.1021/acsapm.8b00105

 

25/02/2019


 news2 130319

 


Results from the AMECRYS Project were presented at the 71st Annual Meeting of the American Physical Society’s Division of Fluid Dynamics (DFD), held at the Georgia World Congress Center in Atlanta, Georgia, US on November 18-20, 2018. The following presentation was delivered by CNRS researcher Sandy Morais as oral presentation: Microfluidic tools for screening Crystallization conditions of monoclonal antibodies, by S. Morais, G. Clisson, J. Leng, J. B. Salmon

 

 

20/11/2018


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The fourth AMECRYS project progress meeting, November 6-7th, 2018, Fujifilm Diosynth Biotechnologies (Billingham)

The fourth AMECRYS project progress meeting took place at Fujifilm Diosynth Biotechnologies (Billingham), UK, on 6th and 7th of November 2018.

 

 

 

 

 

 

 

12/11/2018


 

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The news entitled “Fujifilm, CPI Collaborate on New Technologies for MAb Downstream Processing” appeared on the Biopharm International magazine - The Science & Business of Biopharmaceuticals, giving resonance to the AMECRYS project in one among the main information channels of the Biopharmaceutical industry.
http://www.biopharminternational.com/fujifilm-cpi-collaborate-new-technologies-mab-downstream-processing

 

 

 

06/11/2019


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Two press releases: “AMECRYS Collaboration Reaches Important Project Milestone” and “Fujifilm announces that AMECRYS collaboration reaches project milestone to develop new technologies to improve downstream processing of monoclonal antibodies”, illustrating the achievements of AMECRYS research milestones, were diffused by CPI and FDB, respectively. The latter was also echoed on the US portal of FujiFilm.

 https://www.uk-cpi.com/news/amecrys-collaboration-reaches-important-project-milestone


https://www.fujifilmhealthcare.com/press-release/fujifilm-announces-amecrys-collaboration-reaches-project-milestone-develop-new


https://www.fujifilmusa.com/press/news/display_news?newsID=881545

 

01/11/2018


 

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Results from the AMECRYS Project were presented at the CMAC Open Day 2018, held at the Technology & Innovation Centre, Glasgow, UK, on October 25-26, 2018. The following presentation was delivered by UST researchers as poster presentation: Multiscale template-assisted protein crystallization, by C.J.J. Gerard, D. Lamprou, J.H. ter Horst
https://www.cmac.ac.uk/CMAC_Open_Day_2018.htm

 

 

 

29/10/2019


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First AMECRYS Newsletter

The first AMECRYS Newsletter is ready and downloadable from the official website. Interesting information about the Project and details on the research activity performed up to now by the Consortium Members, are disclosed.

 

 

 

 

 

 

 

08/10/2018


news 051018

 

A new AMECRYS paper published on The Journal of Chemical Physics (American Institute of Physics, i.f. 2.843)

Solvent-mediated interactions between nanostructures: From water to Lennard-Jones liquid, by J. Lam & J. F. Lutsko .
A direct comparison of solvent-mediated forces obtained from molecular dynamics simulations of water, and DFT calculations of LJ using a very generic system made of two nanometric crystalline slabs immersed in a liquid, has been made. DOI: 10.1063/1.5037571

 

 

05/10/2018


news 011018

 

 

European Researchers’ Night 2018 (ERN2018), September 28-29, 2018, University of Calabria

AMECRYS Project promoted during the European Researchers’ Night 2018 (ERN2018), held on 28-29 September 2018 in 27 European countries and beyond. Researchers of the CNR-ITM and UCAL engaging the audience by illustrating the basic techniques in membrane preparation and explaining general objectives, main activities and principal expected benefits of the project. Approximately 50,000 people attended the ERN2018 events at the University of Calabria Campus. (see more at: http://www.fetfx.eu/story/fet-projects-shine-  european-researchers-night-2018/)

 

01/10/2018


MMS

  

3rd International Conference on Applied Mineralogy & Advanced Materials, July 24-26, 2018, Polytechnic University of Bari, Italy

Results from the AMECRYS Project were presented at the 3rd International Conference on Applied Mineralogy & Advanced Materials, July 24-26, 2018, Polytechnic University of Bari, Italy. The following presentation was delivered by UCAL researcher F. P. Nicoletta as invited communication:
Efficient grafting and coating of PVDF membranes for advanced crystallization processes, by E. Pantuso, K. Armentano, P. Formoso, G. De Filpo, G. Di Profio, T. F. Mastropietro, J. Y. Y. Heng, E. Curcio, F. P. Nicoletta

 

 

 

27/07/2018


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Results from the AMECRYS Project were presented at the Euromembrane 2018, held on 9th - 13th July 2018, Valencia, Spain.

The following presentation was delivered by CNR researcher Teresa F. Mastropietro as oral presentation:
Progress in Continuous Template-Assisted Membrane Crystallization  for BioTherapeutics Purification, by  T. F. Mastropietro, C. Meringolo, E. Fontananova, T. Poerio, H. Yang, W. Chen, J. Y. Y. Heng, G. Di Profio

 

 

27/07/2018


roc

 

X-ray diffraction data collection at Diamond LTD Synchrotron (10-12th July 2018)

AMECRYS Researchers Benny D. Belviso and Rocco Caliandro from CNR, working at the Diamond Light Source - UK's national synchrotron science facility, for X-Ray data collection on monoclonal antibody samples.

 

 

 

 

12/07/2018


pap

 

A new AMECRYS paper published on Physical Review E journal (American Physical Society, i.f. 2.284)

Classical density functional theory, unconstrained crystallization, and polymorphic behavior, by J. F. Lutsko & J. Lam.
Application to a Lennard-Jones fluid, results in a demonstration of power of classical density functional theory (cDFT) to describe crystallization in a highly inhomogeneous system. DOI: 10.1103/PhysRevE.98.012604

 

12/07/2018


 

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An article appeared on the official Research and Innovation website of the European Union, highlighting main objectives of AMECRYS project. Success stories: A crystal-clear way to make crucial drugs more affordable.
https://ec.europa.eu/research/infocentre/article_en.cfm?artid=49456

 

 

 

 

06/07/2019


3

 

AMECRYS meetings took place at Centre for Process Innovation (Darlington) and Fujifilm Diosynth Biotechnologies (Billingham), UK, on 26th and 27th of June 2018. Project Coordinator G. Di Profio (CNR) and E. Curcio (UCAL) to start defining prototyping issues with P. McColgan, J. Liddell (CPI) and J. Pullen (FDB).

 

 

26/06/2018


 2 

 

Asian Crystallization Technology Symposium 2018, June 20-22, 2018, Biopolis, Singapore

Results from the AMECRYS Project were presented at the Asian Crystallization Technology Symposium 2018, June 20-22, 2018, Biopolis, Singapore. The following presentation was delivered by IMP researcher X. Li as oral communication:
Bioseparation from protein mixtures,

by X. Li, H. Yang, W. Chen, M. Guo and J. Y. Y. Heng

 

 

 

25/06/2018


1

 

A new AMECRYS’s paper published on ACS Sustainable Chemistry &  Engineering journal (The American Chemical Society, i.f. 6.140)

Tailoring PVDF Membranes Surface Topography and Hydrophobicity by a Sustainable Two-Steps Phase Separation Process,

by C. Meringolo, T. F. Mastropietro, T. Poerio, E. Fontananova, G. De Filpo, E. Curcio, and G. Di Profio.

A sustainable method to produce porous polymeric PVDF membranes with engineered surface features and without using SVHC solvents is proposed.

 

 

 

04/06/2018


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Results from the AMECRYS Project were presented at the Atelier "Exploration du Paysage Energétique : Méthodes & Applications" 2018, 14-16 May 2018, Toulouse (France). The following presentation was delivered by ULB researcher Julien Lam as oral communication:
Crystallization in nanopore, coarse-graining the solvent-mediated forces, by J. Lam and J. Lutsko

 

 

 

 

16/05/2018


Brussel 8may18

 

2nd AMECRYS project progress meeting

The third AMECRYS project progress meeting took place in Bordeaux, France, on 9th-10th of May 2018. Really interesting results presented and many activities planned for the next upcoming months!

 

 

 

 

 

11/05/2018


esrf23apr18

 

 

Data collection on HEL4 single crystals (fAb) and Anti-CD20 powder crystals obtained in dynamic mode (ESRF 23th April 2018)

AMECRYS Researchers Benny D. Belviso and Rocco Caliandro from CNR-IC, working at the European synchrotron facility (ESRF) France, for X-Ray data collection on fragment HEL4 and monoclonal antibody crystalline samples.

 

 

 

 23/04/2018


BCA2018

 

BCA Spring Meeting 2018, University of Warwick, UK, March 26-29th 2018

Results from the AMECRYS Project were presented at the Conference BCA Spring Meeting 2018, March 26-29, 2018, University of Warwick, UK.
The following presentation was delivered by IMP researcher J. Heng as keynote speaker: Template Induced Crystallisation for Polymorph Selection and Protein Crystallisation, by Huaiyu YANG, Wenqian CHEN and Jerry Y. Y. HENG

 

29/03/2018


sciences

 

Printemps des Sciences 2018

AMECRYS Project presented by Université Libre de Bruxelles researchers James Lutsko and Julien Lam at “Printemps des Sciences 2018”, the largest scientific outreach event of the French Community of Belgium, held from 19th to 25th of March 2018. Nearly 40000 people attended to the various scientific activities organized by more than 2000 different researchers! 

 

 

29/03/2018


polymer function application

 

Polymers: Design, Function and Application, Barcelona, Spain, March 21-23th 2018

Results from the AMECRYS Project were presented at the Conference PDFA, Polymers: Design, Function and Application, Barcelona, Spain, March 21-23, 2018.The following presentation was delivered by CNR researchers:Sustainable Preparation of PVDF-based Membranes with Tailored Properties, by T. Poerio, E. Fontananova, C. Meringolo, T. F. Mastropietro, G. Di Profio‚Äč

 

23/03/2018



Nanoscale Journal

 

A new AMECRYS’s paper published on “Nanoscale” journal

A new AMECRYS’s paper published on “Nanoscale” journal (The Royal Society of Chemistry, i.f. 7.367): Lattice induced crystallization of nanodroplets: the role of finite-size effects and substrate properties in controlling polymorphism,

by J. Lam & J. F. Lutsko.
Computer simulations of the crystallization of nanoscale droplets deposited on a solid substrate show that the resulting crystal structure is controlled by the lattice spacing of the substrate.

 

 

08/03/2018


innovative UK

 

Results from the AMECRYS Project were presented at the event “Downstream process development of next generation challenging proteins”, organized by The Knowledge Transfer Network (KTN), in partnership with GlaxoSmithKline (GSK) and GE Healthcare Life Sciences (GE), held at the GlaxoSmithKline Medicines Research Centre in Stevenage (UK) on the January 30 2018. The following presentation was delivered by  FujiFilm Diosynth Biotechnologies (FDB) researchers: Incorporation of High Throughput Resin Screening Strategies for Rapid Development of a Robust Purification Method of a Model VH Domain Antibody Fragment, by James Pullen. Over 100 delegates from industry, academia and research institutes attended to the event!

 

 

 

12/02/2018


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Italian National Award for Innovation, 30th December 2017, Naples

CNR (G. Di Profio) and UCAL (E. Curcio) researchers, promoting AMECRYS Project at the Italian National Award for Innovation (PNI  2017) event, Napoli, November 30th - December 1st, 2017.

 

 

 

30/12/2017


 

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Innovation Radar, an initiative supported by the European Commission focusing on the identification of high potential innovations and the key innovators behind them in Horizon 2020 projects, identified AMECRYS partner CNR as developer of the Innovation that is actively exploring value creation opportunities: “Improvements on the PVDF membrane production and derivative applications of technology”.
https://www.innoradar.eu/innovation/23238

 

 

 

 


chromato

 

Anything But Conventional Chromatography Workshop, 22-24th of November, 2017, Lisbon.

Results from the AMECRYS Project were presented at the ABC2 - Anything But Conventional Chromatography Workshop. Following presentation was delivered by Imperial College London researchers:
Seeding and Continuous Protein Crystallisation for Bioseparation

by Huaiyu Yang, Wenqian Chen and Jerry Y. Y. Heng

 

 

23/11/2017


meetingUE

 

AMECRYS Project’s review meeting

First AMECRYS review meeting took place on 14th of November 2017 at Research Executive Agency (REA), Brussels. Very fruitful discussions with experts and project officer occurred!

 

 

 

14/11/2017


nano 

 

 

First AMECRYS’ paper published

published on “Nanoscale” journal (The Royal Society of Chemistry, i.f. 7.367) Solute particle near a nanopore: influence of size and surface properties on the solvent-mediated forces

by J. Lam & J. F. Lutsko.

 

 

31/10/2017


giornate Dip

 

 

DSCTM conference, from 19th to 20th of October, 2017, Alghero.

Results from the AMECRYS project were showed.
The following presentation was delivered by IC-CNR

Tacking on protein crystallization challenge by hybrid materials

by B.D. Belviso

 

 

 


19-20/10/2017


danilo rocco SAXS

 

 

 

AXS Data Collection (Diamond Synchrotron)

AMECRYS’s Researchers from CNR-IC working at the Diamond Light Source is the UK's national synchrotron science facility, for SAXS and X-Ray data collection on monoclonal antibody samples.

 

 

 

 

21/09/2017


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2nd AMECRYS project progress meeting

The second AMECRYS project progress meeting took place in web-conference on 20th-21st of September 2017 and resulted in a detailed report of the work performed in the previous months and the activities planned for the next semester.

 

 

 

 

 21/03/2017


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20th International Symposium on Industrial Crystallization (ISIC20), from 3rd to 6th of September, 2017, Dublin.

Results from the AMECRYS project were presented at (ISIC20).
The following presentation was delivered by University of Strathclyde researchers:
Effect of Templates on Protein Nucleation Rates from Probability Distributions of Induction Times, by E. Hosseini, D. Lamprou, J.H. ter Horst

 

 

05/09/2017


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Thermodynamics 2017 conference, from 5th to 8th of September, 2017, Edinburg.

Results from the AMECRYS project were presented at the Thermodynamics 2017 conference (Edinburg, UK). The following presentation was delivered by Universite Libre de Bruxelles researchers:
Depletion forces acting on a solute particle near a cylindrical pore, by J. Lam, J.F. Lutsko

 

 

 05/09/2017


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British Association of Crystal Growth (BACG) 2017, from 27th to 30th of June, Manchester.

Results from the AMECRYS project were presented at the annual meeting of the British Association of Crystal Growth (BACG) 2017 (Manchester, UK).
The following presentation was delivered by University of Strathclyde researchers:
Effect of Template Particles on Protein Nucleation Rates from Probability Distributions of Induction Times, by E. Hosseini, D. Lamprou, J.H. ter Horst

 

 

27/06/2017 


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CBMNET Membrane Engineering of Lipids and Proteins for Industrial Biotechnology and Bioenergy, from 5th to 6th of June, 2017, Glasgow.

Results from the AMECRYS project were presented at the CBMNET Membrane Engineering of Lipids and Proteins for Industrial Biotechnology and Bioenergy (Glasgow).

The following presentation was delivered by Fujifilm Dyosinth Biotechnologies researchers: Challenges with Escherichia coli Outer membrane for Periplasmic release, by C. Lennon

 

 

05/06/2017


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An overview of AMECRYS, explaining the main concept of the project and the consortium, was given by the project coordinator during the 1h 30min broadcasting of UNICALBAR (https://www.facebook.com/unicalbar/?fref=mentions), the programme of PonteRadio UNICAL, the web radio of the Univesrity of Calabria.

 

 

 

12/06/2017


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1st AMECRYS project progress meeting

The first AMECRYS project progress meeting took place on the 7th of March 2017 and resulted in a detailed description of the work performed in the first months and the work-plan covering the period up to September 2017.

 

 

 

07/03/2017 


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AMECRYS video

Here you can watch the first 4-minute AMECRYS video, released to explaining the main concept of the project:

 

 

 

 

 21/03/2017


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A press release entitled “Low-cost monoclonal antibodies: AMECRYS project now underway” appeared on the site ResearchItaly, the portal of Italian research, promoted by the Italian Ministry of Education, University and Research - Directorate General for Research Coordination, Promotion and Valorization, illustrating the main objectives and the Consortium of AMECRYS.

 

 

04/11/2016


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AMECRYS Kick-off meeting

The first AMECRYS project progress meeting took place on the 5-7th of October 2016 at at University of Calabria (Rende, CS, Italy)

 

5-7/10/2016